Diabetes – North East Endocrine Network

Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort

David Bishop — Fri, 08 Dec 2017 16:27:51 +0000

Roy Taylor, Wilma S. Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Naveed Sattar, Paul Welsh, Carl Peters, Sviatlana Zhyzhneuskaya, Kieren G. Hollingsworth, Ahmad Al-Mrabeh, Angela M. Rodrigues, Lucia Rehackova, Ashley J. Adamson, Falko F. Sniehotta, John C. Mathers, Hazel M. Ross, Yvonne McIlvenna, Sharon Kean, Ian Ford, Alex McConnachie, Michael E. J. Lean

Diabetologia

Published 30 November 2017

https://doi.org/10.1007/s00125-017-4503-0

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

David Bishop — Wed, 06 Dec 2017 14:02:14 +0000

Prof Michael EJ Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Carl Peters, Sviatlana Zhyzhneuskaya, Ahmad Al-Mrabeh, Kieren G Hollingsworth, Angela M Rodrigues, Lucia Rehackova, Prof Ashley J Adamson, Prof Falko F Sniehotta, Prof John C Mathers, Hazel M Ross, Yvonne McIlvenna, Renae Stefanetti, Prof Michael Trenell, Paul Welsh, Sharon Kean, Prof Ian Ford, Alex McConnachie, Prof Naveed Sattar, Prof Roy Taylor

The Lancet. DOI: 10.1016/S0140-6736(17)33102-1

The DiRECT study, led by Newcastle University has found that almost half of the patients with Type 2 diabetes supported by their GPs on a weight loss programme were able to reverse their diabetes in a year.

This study was funded by Diabetes UK and has also received attention in the mainstream media, highlighting the quality research that takes place in our region.

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial

Owain Leng — Tue, 14 Feb 2017 10:25:46 +0000

Wilma S. Leslie, Ian Ford1 Naveed Sattar, Kieren G. Hollingsworth, Ashley Adamson, Falko F. Sniehotta, Louise McCombie, Naomi Brosnahan, Hazel Ross, John C. Mathers, Carl Peters, George Thom, Alison Barnes, Sharon Kean, Yvonne McIlvenna, Angela Rodrigues, Lucia Rehackova, Sviatlana Zhyzhneuskaya, Roy Taylor and Mike E. J. Lean

BMC Family Practice BMC series – open, inclusive and trusted 2016 17:20

DOI: 10.1186/s12875-016-0406-2

Modulation of insulin dose titration using a hypoglycaemia-sensitive algorithm: insulin glargine versus neutral protamine Hagedorn insulin in insulin-naïve people with type 2 diabetes

admin — Mon, 28 Sep 2015 20:02:48 +0000

Home PD, Bolli GB, Matheiu C, Deerochanawong C, Landgraf W, Candelas C, Pilorget V, Dain M-P, Riddle MC. Modulation of insulin dose titration using a hypoglycaemia-sensitive algorithm: insulin glargine versus neutral protamine Hagedorn insulin in insulin-naïve people with type 2 diabetes. Diabetes Obes Metabol 2015; 17: 15-22. doi: 10.1111/dom.12329

Demonstration of an intrinsic relationship between endogenous C-peptide concentration and determinants of glycemic control in type 1 diabetes following islet transplantation

admin — Mon, 28 Sep 2015 20:02:18 +0000

Brooks AM, Oram R, Home P, Steen N, Shaw JAM. Demonstration of an intrinsic relationship between endogenous C-peptide concentration and determinants of glycemic control in type 1 diabetes following islet transplantation. Diabetes Care 2015; 38: 105-112.

Risk and Recurrence of Serious Adverse Outcomes in the First and Second Pregnancies of Women With Preexisting Diabetes

admin — Mon, 28 Sep 2015 19:59:32 +0000

Tennant PWG, Bilous RW, Prathapan S, Bell R Risk and Recurrence of Serious Adverse Outcomes in the First and Second Pregnancies of Women With Preexisting Diabetes. Diabetes Care 2015; 38:4 610-619; published ahead of print January 8, 2015, doi:10.2337/dc14-1888

Diabetic Kidney Disease: A report from an ADA Consensus Conference

admin — Mon, 28 Sep 2015 19:58:38 +0000

Tuttle KR, Bakris GL, Bilous RW et al Diabetic Kidney Disease: A report from an ADA Consensus Conference. Diabetes Care 2014; 37:10 2864-2883; doi:10.2337/dc14-1

Pre-existing diabetes, maternal glycated haemoglobin, and the risks of fetal and infant death: a population-based study

admin — Mon, 28 Sep 2015 19:57:59 +0000

Tennant PW, Glinianaia SV, Bilous RW, Rankin J, Bell R.Pre-existing diabetes, maternal glycated haemoglobin, and the risks of fetal and infant death : a population-based study. Diabetologia 2014; 57: 285-94

Effects of Vildagliptin on Hepatic Steatosis

admin — Mon, 28 Sep 2015 19:56:40 +0000

Mavin Macauley, Kieren G. Hollingsworth, Fiona E. Smith, Peter E. Thelwall, Ahmad Al-Mrabeh, Anja Schweizer, James E. Foley, Roy Taylor J Clin Endocrinol Metab. 2015 April; 100(4): 1578–1585. Published online 2015 January 9. doi: 10.1210/jc.2014-3794